A system, method and software for isolating information handling system memory system devices are disclosed. In dual-channel double-data-rate memory system implementations, teachings of the present disclosure facilitate accurate identification of memory system devices that fail diagnostic testing or cause memory errors. A BIOS level application is provided which permits user or application selection and isolation of memory system devices or components, thereby eliminating the need for physical removal of such components during testing as well as permitting continued use of the information handling system with defective memory system devices isolated.