It is intended to provide a protein participating in the regulation of
sugar production, a polynucleotide encoding the same, a method of
screening a compound participating in the regulation of sugar production
and a drug for treating or preventing diabetes which contains the
compound participating in the regulation of sugar production. A
polynucleotide encoding a protein specifically binding to a substance
WF00144 is found out from rat liver cells and thus a protein
participating in the regulation of sugar production and a polynucleotide
encoding the same are provided. Moreover, a method and a substance
relating to a method of treating and preventing diabetes are found out
and thus a method of treating diabetes relating to the regulation of
sugar production relating to the method of treating and preventing
diabetes is provided.