The present invention is concerned with a method and composition for use in the medical art. It relates to the prevention and/or minimization of Spondyloarthropathies (SpA) and/or SpA enthesitis. SpA are an important group of chronic inflammatory disorders, affecting both the axial and peripheral skeleton. A particular method and composition optionally including a suitable dispensing device for such compositions can be used for ameliorating or preventing SpA. The invention applies to human and veterinary applications. To date, no single therapeutic approach has proven universally effective in preventing SpA or ameliorating SpA. Therefore, there is a need for compositions and methods which may be used safely and effectively to prevent SpA in a variety of different contexts.