Systems and methods for compensation of sensor degradation in multi-shooter detection systems are described. In such systems, shooter position and trajectory can be estimated precisely from the shockwaves produced at the plurality of sensors by the incoming shots. However, sensor positions can shift and the performance of some sensors may degrade for various reasons. To compensate for sensor degradation that may occur over the life of a long-deployed system, the shooter estimation algorithms are dynamically adapted by performing a least-squares regression analysis of the shockwave arrival times to obtain a time residual for each shot, observing multiple shots, and weighting the individual contributions of the sensors as a function of the time residuals for the multiple shots.