Methods of eliciting a TLR8-mediated cellular response are disclosed. Such
methods include administration of either a TLR8 agonist or a TLR8
antagonist to an IRM-responsive cell so that the IRM compound affects at
least one TLR8-mediate cellular signaling pathway. In some cases, the
method may provide prophylactic or therapeutic treatment for a condition
treatable by modulating a TLR8-mediated cellular pathway.