To present a reaction system that efficiently catalyzes an enantio selective asymmetric nucleophilic addition reaction of an .alpha.-iminophosphonic acid ester. An optically active .alpha.-amino-.gamma.-oxophosphonic acid derivative is produced through an asymmetric addition reaction of an .alpha.-iminophosphonic acid ester and a nucleophilic agent (for example, a silyl enol ether).

 
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> Process for the synthesis of enantiomeric indanylamine derivatives
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