Systems and methods for detecting image quality defects in images rendered by a rendering device. Original image data is rendered by an image rendering device, and the rendered image is captured by an image capturing device. Regions of interest may be identified to provide information indicating where image quality defects of the rendering device, may be identified. At each region of interest, the original image data may be compared to the captured image data of a corresponding region of interest to determine color difference of the captured image at the region of interest. The color difference may be subsequently converted from a device independent color space to a device dependent color space. Based on the converted color difference and input intensity of the original image data at the region of interest, a colorant error may be determined for the region of interest, and/or a scan line and a row line including the region of interest.