Method and system for processing natural gas containing contaminants through the use of one or more rotary screw compressors. A natural gas containing a contaminant (e.g., water or carbon dioxide and/or hydrogen sulfide) and a contaminant removing agent are combined and processed within a rotary screw compressor. The contaminant removing agent may be a dehydrating agent such as a glycol or a carbon dioxide and/or hydrogen sulfide removing agent such an amine. The method and system of the present invention also may employ a series of rotary screw compressors to process natural gas containing a plurality of contaminants.