A system and method for mapping the sensitivity of MR coils includes a neural network or other computer intelligence trained from sample MR data to determine coil sensitivity profiles or sensitivity normalizations. Once the network is trained, subsequent coil mapping determinations may include fewer mapping acquisitions per coil. The resulting sensitivity map can be used in compensating for B1 inhomogeneities, parallel imaging reconstruction, generating tailored excitation currents for each individual coil, RF shimming, or other processes.