Novel compounds of the formula I ##STR00001## in which R.sup.1, R.sup.2, R.sup.3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.

 
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> Pyrimidine compound and medical use thereof

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