The present invention provides a compound having the following general
formula (I) which is useful as a neurokinin receptor antagonist:
##STR00001## (wherein, R.sup.1, R.sup.2: optionally substituted
(hetero)aryl, R.sup.3: --CO--R.sup.4, --CO--O--R.sup.4, etc., R.sup.4:
alkyl, cycloalkyl, etc., A: CH.sub.2, CO, SO.sub.2, B: a single bond,
etc., D: oxygen, CH.sub.2, E: alkylene, alkenylene, n: 1 to 3).