A low pressure liquid chromatographic cartridge is provided having a
tubular polymer container adapted to receive a chromatographic packing
material. The container has an outlet port located at a downstream end of
the container and container threads formed on an upstream end of the
container. A polymer cap having cap threads located on the cap
threadingly engage the container threads. An inlet port is located on an
upstream end of the cap. A flange depends from the cap and mates with the
lip of the container to form a fluid tight seal between the polymer cap
and container suitable for use in low pressure liquid chromatography. A
locking tab on a skirt of the cap engages a recess on the container when
the seal engages the cap and container to lock the cap in position
relative to the container. Alternatively, continuous screw threads on the
cap and container may hold the parts together.