The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula having the structural Formula I, II, III or IV, stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, Y.sup.1, Y.sup.2, R.sup.1, n, R.sup.3, R.sup.8, R.sup.9, R.sup.10, L.sup.1, L.sup.2, Ar.sup.1 and Ar.sup.2 are defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.