The present invention provides methods of coupling carbon-containing
compounds using a transition metal or transition metal complex on a solid
support. The solid support can include alkaline earth metal salts,
including carbonate and sulfate salts. The transition metals can include
palladium or nickel metal. The method can include combining two carbon
containing compounds and a transition metal or transition metal complex
on a solid support in the presence of a solvent, desirably an alcohol.