Prefetch information is generated for multi-block indirect memory access chains. A method may include selecting a chain of indirect memory accesses of a procedure, the chain comprising a head access that does not depend for its address on another prefetch candidate memory access within the procedure and an indirect access that depends for its address on the head access. The method may further include determining a prefetch-ahead value for the chain, and generating a load operation corresponding to the head access that specifies a target memory address that is dependent upon the prefetch-ahead value and an address of the head access. The method may further include, for a terminal indirect access of the chain, generating a respective prefetch operation that is dependent for its address computation on results of preceding load operations in the same manner as its corresponding terminal indirect access depends upon preceding accesses in the chain.