A toothpaste tube squeezer has first and second squeezing blocks for holding a toothpaste tube therebetween. A first clamping mechanism is positioned toward an opening end of the toothpaste tube to apply pressure to the first and second squeezing blocks to squeeze the toothpaste tube. A second clamping mechanism is positioned toward a sealed end of the toothpaste tube to release pressure on the blocks. Both squeezing blocks may have slightly outwardly curved surfaces to contact the toothpaste tube. As the second clamping mechanism is loosened to release pressure applied at the sealed end of the toothpaste tube, a gap may increase between the squeezing blocks at the sealed end of the toothpaste tube. Due to the slightly curved surfaces of the squeezing blocks and the increasing gap, a squeezing pressure moves further up the toothpaste tube in a direction from the sealed end to the opening end.