The key obstacle for current resuscitation is the acutely limited time window. The major reason for the limited time window is that the brain and spinal cord are extremely vulnerable to hypoxic-ischemic insult. A method and a lymph-like fluid composition for resuscitation of cardiac arrest are provided. The method includes steps of inhibiting CSF production, removing CSF, replacing the CSF with invented lymph-like fluid composition plus conventional CPR. The lymph-like fluid composition includes polypeptides, insulin, elevated magnesium concentration and ATP in artificial CSF.