In a method of canceling interference, a base station selects a known highest data rate user transmission from a received first signal containing a group of user transmissions. The known highest rate user transmission may be configured as one or more frames, each frame including a control preamble and a plurality of encoded sub-frames. The control preamble and encoded sub-frames may be decoded, and the decoded sub-frames may be used for removing interference caused by the known highest rate user transmission to all remaining transmissions of the group.