The present invention refers to an considerably improved medicinal preparation and its synthesizing method, in particular for allowing to affect the osteoreparative process due to stimulation of the prolific and functional activity of osteoblasts without risk of development of the immunologic conflict reactions. According to the invention it is provided a medicinal combined preparation for treating diseases of bone tissue containing at least a medicinal component, especially having anti-inflammatory and/or anti-bacterial properties and nano-sized crystalline hydroxyapatite having average dimensions with a length equal to 0.06 .mu.m.+-.50%, a width equal to 0.015 .mu.m.+-.50% and a thickness equal to a single transmission of crystalline lattice of the hydroxyapatite, in particular to 0.00068 .mu.m or 0.000814 .mu.m depending on direction of the symmetry axis of the crystalline cell.