A combined filter cartridge and manifold for use in a water purification system or the like, to facilitate substantially drip-free filter cartridge removal and replacement. The filter cartridge includes water inlet and outlet ports for respective connection with inlet and outlet fittings on the manifold. A pivoting manifold cap normally overlies and retains the filter cartridge in connected relation with the manifold fittings and a water supply coupled to the manifold. Pivoting movement of the manifold cap toward an open position shuts off the water supply and then permits filter cartridge separation from the manifold, with check valves at the manifold inlet/outlet fittings and cartridge inlet/outlet ports preventing significant water leakage. Upon installation of a replacement filter cartridge and return movement of the manifold cap to the initial closed position, cam elements on the manifold cap and filter cartridge draw the cartridge inlet/outlet ports into secure slide-on connection with the manifold inlet/outlet fittings before resuming connection with the water supply.