A method of managing the valves of a simulated moving bed separation system comprising at least one column of adsorbent beds split into several zones delimited by injection and draw-off points, allowing finer monitoring of a determined concentration profile. The method comprises, during each period between the shift times of the injection and draw-off points, in opening and closing a first valve located at one end of a zone according to a determined law, while opening and closing the valve downstream from the first valve in relation to the direction of flow of the recirculation flow, according to the same law with a lag, referred to as overlap time, in relation to the first valve, which is less than or equal to the period, the law imposing a constant total flow rate for the flow passing through the two consecutive valves throughout the overlap time. Applications are any simulated moving bed separation system, preferably those used for relatively small-tonnage production such as fine petrochemistry, pharmaceutical industry, certain food processing industries, etc.

 
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