This invention provides remedies or prophylactics for diseases in association with chemokines such as MIP-1 .alpha. and/or MCP-1. Namely, remedies or prophylactics for diseases in association with the chemokines such as rheumatoid arthritis or nephritis contain, as the active ingredient, cyclic amine derivatives represented by the following formula (I), pharmaceutically acceptable acid addition salts thereof or pharmaceutically acceptable C.sub.1-C.sub.6 alkyl addition salts thereof.