A system and method is provided for managing RFID readers. The system and method manages RFID readers by controlling the RFID readers to reduce interference between RFID transmissions. The system and method locates RFID readers, including mobile and fixed RFID readers, and controls the transmitting of the RFID readers such that proximate readers do not transmit simultaneously. This reduces the interference between RFID readers, and thus can improve the reliability and accuracy of the RFID system.