An acupressure apparatus for applying pressure to the LI4 acupressure points on both of a user's hands simultaneously includes a pressure applicator assembly with an upper plate and a lower plate overlying each other and pivotally connected at one aligned edge, each plate having a pair of knobs with the respective upper and lower knobs aligned to come together and apply pressure to a user's hand placed between them. In a first embodiment the upper plate of the pressure applicator assembly is connected to a footplate by a flexible cable so that a user may hold the pressure applicator assembly in his or her hands, place his or her feet on the footplate with the lower plate of the pressure applicator assembly on his or her knees, and apply pressure to the hands by raising his or her knees to bring the lower plate and knobs upward against the upper plate and knobs. In a second embodiment a cable assembly with an outer tube and an inner wire is connected between the pressure applicator assembly and a foot pedal assembly so that depression of the foot pedal while a user holds the pressure applicator assembly brings the plates and knobs together to apply pressure to the user's hands.