Disclosed herein is an analyte sensing device capable of continuously
monitoring metabolic levels of a plurality of analytes. The device
comprises an external unit, which, for example, could be worn around the
wrist like a wristwatch or could be incorporated into a cell phone or PDA
device, and an implantable sensor platform that is suitable, for example,
for implantation under the skin. The external device and the internal
device are in wireless communication. In one embodiment, the external
device and the internal device are operationally linked by a feedback
system. In one embodiment, the internal device is encapsulated in a
biocompatible coating capable of controlling the local tissue environment
in order to prevent/minimize inflammation and fibrosis, promote
neo-angiogenesis and wound healing and this facilitate device
functionality.