An electronic book with multimedia play function includes a main body and an AV play unit. The main body includes a back cover, a front cover, a display, and a plurality of movable leaves located between the back and the front cover. The display is located at a predetermined position on an upper side of the back cover, and each of the movable leaves has a window formed at a position corresponding to the display. The AV play unit includes a microprocessor, a built-in AV data memory, a display interface, a sound interface, and a leaf detecting unit, which is connected to the microprocessor for detecting each individual one of the movable leaves.