The invention relates to use of a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: ##STR00001## wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein for treating a variety of disease states. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of GSK3.beta., such as Pick's disease.