A 5-membered cyclic compound of the formula: ##STR00001## wherein X is oxygen or sulfur, R.sup.1 is hydrogen, substituted or unsubstituted alkyl, etc., R.sup.2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y.sup.1 is a direct bond, substituted or unsubstituted alkylene, --CO(CH.sub.2).sub.n--, etc., the wavy line means (E)-configuration or (Z)-configuration, R.sup.3 is substituted or unsubstituted aryl, etc., Y.sup.2 is substituted or unsubstituted alkylene, etc., R.sup.4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R.sup.5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.