The present invention relates to compounds having the formula, ##STR00001## and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted pyridyl, ring; R.sub.2 is alkyl or an amino group as defined herein; and Z is optionally-substituted C(.dbd.O)NR.sub.6, wherein R.sub.6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing pharmaceutical compositions for treating p38 kinase related conditions and/or in methods of treating conditions associated with the activity of p38 kinase in a patient.