Methods and systems are provided for downhole analysis of formation fluids by deriving differential fluid properties and associated uncertainty in the predicted fluid properties based on downhole data less sensitive to systematic errors in measurements, and generating answer products of interest based on the differences in the fluid properties. Measured data are used to compute levels of contamination in downhole fluids using, for example, an oil-base mud contamination monitoring (OCM) algorithm. Fluid properties are predicted for the fluids and uncertainties in predicted fluid properties are derived. A statistical framework is provided for comparing the fluids to generate robust, real-time answer products relating to the formation fluids and reservoirs thereof. Systematic errors in measured data are reduced or eliminated by preferred sampling procedures.