An approach for estimating and removing crosstalk and other interference in a communications receiver is disclosed. The approach enables crosstalk and interference of arbitrary origin and power spectral density to be removed from a received signal, thereby improving the signal to noise ratio (SNR). A receiver samples the received signal at a rate N times the required sampling rate, and splits the signal into N separate observation sequences, all at the required sampling rate. The N observation sequences are separated into a data signal and a crosstalk signal. The crosstalk signal is discarded, while the data signal is passed to equalization and demodulation circuits of the receiver.