In a method and apparatus for analyzing multivariable data sets, a general
computerized platform is provided for evaluating the relationship between
large number of measurements of sets of variables characterizing
components of complex states of a system under induced stimulation or
controlled conditions. The linked responses of variables and their
temporal relations tell about the network of interactions and their
hierarchy. Processing of data sets by a simple neural network gives a
matrix of weight parameters, that allow to identify fingerprints of
complex states characterized by patterns of measured variable and
estimate the interactions between the components characterized by the
measured variables. The results are provided numerically and by
color-coded presentation indicating dominating relations between
variables and strongly responding variables. When applied to dynamic
responses of a system, the analysis can construct a schematic
hierarchical architecture of the network of interaction between the
components of the studied system. Applications in biology include
analysis of measurements characterizing responses of molecular components
in cells under changes induced by stimuli (e.g. drugs, growth factors,
hormones, mutations or forced expression of a proteins), and
identification of complex cellular states (e.g. proliferation,
differentiation, transformation, starvation, necrosis, apoptosis, and the
time dependencies of the above effects).