A system and method may generate a radiological request by which to conduct a radiological procedure that employs a series of procedural steps to acquire internal images of a patient. Each step may have a corresponding protocol item which affects image quality and the time required to complete the step. A database may be maintained that includes protocol items and patient characteristic data. A rule-based algorithm may accept patient characteristic data as input. Based upon one or more patient characteristics, an overall protocol by which to conduct the radiological procedure may be determined. The tailored protocol may include steps that are selected, omitted, and/or altered based upon a patient characteristic. The patient characteristics may be medical restrictions, such as age, pregnancy, allergies, artificial joints, or other limitations. As a result, the protocol items may be automatically selected based upon patient specific characteristics, and/or an anatomical structure to be examined.