The present invention relates to methods and components for increasing
adhesion of an elution control matrix to a polymeric substrate, and
medical devices including such components. In an embodiment, the
invention includes a medical device including a substrate having a
surface, the substrate comprising a polysiloxane, a parylene layer
contacting the surface of the substrate, and an elution control matrix
contacting the parylene layer, the elution control matrix comprising a
polymeric matrix and an active agent dispersed within the polymeric
matrix. Other embodiments are included herein.