The present invention discloses a method and a device for independent color management by using a look-up table (LUT) so as to adjust the color saturation of a single color independently. The method comprises steps of: receiving a color signal of an input pixel; determining color flags and initial saturation values from the color signal by using a look-up table (LUT); obtaining user-controlled color gains according to the color flags; multiplying each of the initial saturation values with one of the corresponding user controlled color gains so as to output an adjusted saturation value; determining a final gain from each the adjusted saturation value by bilinear interpolation according lower-bits of the color signal; and obtaining a new color signal according to the final gain and the color signal. The device comprises a look-up table circuit, defining color flags and initial saturation values as a plurality of points on a coordinate system and receiving a color signal as to output a plurality of signals; a gain output device, receiving the color flags, the initial saturation values and user controlled color gains as to output adjusted saturation gain signals according to the initial saturation values and the user controlled color gains; and an operation unit, receiving the color signal, the initial gain signals as to adjust the color signal according to lower bits of the color signal and the adjusted saturation gain signals.