Defect detection in a software system made of multiple computer program programs is facilitated by using information about cross-program interactions and dependency relationships between programs to analyze the individual programs in such a way that the behavior of the system as a whole is accurately represented. A list of dependency relationships is read in; these dependency relationships are used to determine an order in which the programs should be analyzed. The programs are then analyzed in that order. Information from the analysis of the programs is used to inform the analysis of subsequently-analyzed programs.