The invention relates to acylhydrazone derivatives of formula (I), which
are SGK inhibitors and can be used for the treatment of diseases and
afflictions associated with SGK, such as diabetes, obesity, metabolic
syndrome (dyslipidaemia), systematic and pulmonary hypertension,
cardiovascular diseases and kidney diseases and in general for all types
of fibroses and inflammatory processes. In said formula: R.sup.1 and
R.sup.5 independently of one another represent H, OH, OA, OAc or methyl;
R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and
R.sup.10 independently of one another represent H, OH, OA, OAc,
OCF.sub.3, Hal, NO.sub.2, CF.sub.3, A, CN, OSO.sub.2CH.sub.3,
SO.sub.2CH.sub.3, NH.sub.2, or COOH; R.sup.11 represents H or CH.sub.3; A
represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents
CH.sub.2, CH.sub.2CH.sub.2, OCH.sub.2 or --CH(OH)-- and Hal represents F,
Cl, Br or I. ##STR00001##