Compositions for maintaining, strengthening, improving, or promoting eye health comprise .alpha.-lipoic acid, ascorbic acid, and .alpha.-tocopherol, or pharmaceutical equivalents thereof. The compositions are useful to prevent, stabilize, reverse and/or treat visual acuity loss in subjects having, or being at risk of developing, an ocular disease. The compositions can further comprise one or more other antioxidants, beneficial minerals, and/or nutritional or dietary materials.