A flexible cable and a disk drive with a flexible cable are provided. The disk drive includes a main base, a pickup base installed on the main base and provided with parts for recording and reproducing of signals on and from a disk, including an optical pickup linearly movable within a predetermined region, a board fixedly installed on a side of the main base and configured to control driving of the parts, including the optical pickup, and a flexible cable. The flexible cable includes a folded portion formed at a portion of a flexible cable main body so as to cause both ends of the flexible cable main body to extend in the same direction, wherein ends of the flexible cable connect to the optical pickup and the board at opposite positions, respectively, so as to transmit signals therebetween. With this structure, it is possible to efficiently use inner space of the disk drive.