Aspects of the invention provide a droplet discharge device, a method of discharging a droplet, a method of manufacturing an electro-optical device, and electronic equipment that can grossly reduce a disposed liquid and effectively utilize more discharging liquid as compared with a related art manner in which a nozzle clogging of a head is recovered by a cleaning suction. The droplet discharge device that discharges a droplet to a workpiece can include a head that has a plurality of nozzles, a suction device for sealing and suctioning a nozzle surface of the head, and a controller by which the nozzle surface is sealed by the suction device and the droplet is discharged to the suction device from the nozzle, and the nozzle surface is kept moist by leaving the nozzle surface sealed by the suction device, if the number of clogged nozzle exceeds a predetermined number.