A device for an optically controlled micro-manipulation of biological specimens includes at least one micro-manipulator with at least one motor-displaceable cytotechnical instrument holder elements, and a microscope which has at least one functional motor-displaceable element coupled with the motor-displaceable holder in such fashion that, using a control element, a common displacement or adjustment of the holder and a displacement of the at least one functional element of the microscope can be executed in a coordinated fashion so that upon changing a size of a field of view by changing a microscope objective lens, a covered range of displacement of a cytotechnical instrument using the holder is adapted to a new field of view.