Disclosed are compounds of the formula ##STR00001## or a pharmaceutically
acceptable salt thereof, wherein: M.sup.1 and M.sup.3 are CH or N;
M.sup.2 is CH, CF or N; Y is --C(.dbd.O)--, --C(.dbd.S)--,
--(CH.sub.2).sub.q--, --C(.dbd.NOR.sup.7)-- or --SO.sub.1-2--; Z is a
bond or optionally substituted alkylene or alkenylene; R.sup.1 is H,
alkyl, alkenyl, or optionally substituted cycloalkyl, aryl, heteroaryl,
heterocycloalkyl or a group of the formula: ##STR00002## where
ring A is a monoheteroaryl ring; R.sup.2 is optionally substituted
alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; and the
remaining variables are as defined in the specification; compositions and
methods of treating allergy-induced airway responses, congestion,
obesity, metabolic syndrome nonalcoholic fatty liver disease, hepatic
steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular
carcinoma or cognition deficit disorders using said compounds, alone or
in combination with other agents.
