The present invention pertains to methods utilizing ozone treatment for abating allergens, pathogens, odors, and volatile organic compounds. The methods can be employed to abate pollutants, bacteria, viruses, mold, dander, funguses, dust mites, animal and smoke odors, and the like. The methods employ specific combinations of ozone concentration, hydrogen peroxide concentration, temperature, and humidity delivered over a specified period of time to achieve satisfactory abatement of the allergen, pathogen, odor, or volatile organic compound.