There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from --O-- and --S--; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C.sub.1-C.sub.4 alkyl and C.sub.1-C.sub.4 alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C.sub.1-C.sub.4 alkyl, and C.sub.2-C.sub.8 alkyl, C.sub.2-C.sub.8 alkenyl, C.sub.3-C.sub.8 cycloalkyl and C.sub.4-C.sub.8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy, C.sub.1-C.sub.4 alkyl --S(O).sub.n-- where n is 0, 1 or 2, --CF.sub.3, --CN and --CONH.sub.2; Y is selected from dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, and thienopyridyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy, C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2, nitro acetyl, --CF.sub.3, --SCF.sub.3 and cyano; Z is selected from H, OR.sub.3 or F, wherein R.sub.3 is selected from H, C.sub.1-C.sub.6 alkyl and phenyl C.sub.1C.sub.6 alkyl; R.sub.1 and R.sub.2 are each independently H or C.sub.1-C.sub.4 alkyl; and pharmaceutically acceptable salts thereof. ##STR00001##