A polymer pipe for hot fluids, usually hot water is described. The pipe is characterised in that it comprises a multimodal polyethylene with a high molecular weight (HMW) fraction and a low molecular weight (LMW) fraction where said HMW fraction has a density of at least 0.920 g/cm.sup.3, and that the multimodal polyethylene has a density of 0.921-0.950 g/cm.sup.3 and has a time to failure at 95.degree. C. and 3.6 MPa of at least 165 h determined according to DIN 16 833 and a modulus of elasticity of at most 900 MPa determined according to ISO 527-2/1B. Preferably, the multimodal polyethylene is a bimodal polyethylene, the LMW fraction having a density of 0.955-0.975 g/cm.sup.3, the HMW fraction having a density of 0.920-0.940 g/cm.sup.3, and the weight ratio of the LMW fraction to the HMW fraction being from 30:70 to 55:45.

 
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> Epitope identification and modification for reduced allergenic activity in proteins targeted for transgenic expression

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