A process for the preparation of citalopram and the pharmaceutically
acceptable salts therof is disclosed by reacting 5-cyanophthalide with a
4-fluorophenyl magnesium halide, reducing the
3-hydroxymethyl-4-(4-fluorobenzoyl)benzonitrile with an agent reducing
ketones to alcohols, submitting the thus-obtained
3-hydroxymethyl-4-[(4-fluorophenyl)hydroxymethyl)benzonitrile to a
cyclization reaction to give
1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile without
1,1-bis(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile and
treating 1,1-bis(4 fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile
with a 3-(dimetylamino)propyl halide in the presence of a base.