A method, apparatus and computer instructions for hardware assist for autonomically patching code. The present invention provides hardware microcode to a new type of metadata to selectively identify instructions to be patched for specific performance optimization functions. The present invention also provides a new flag in the machine status register (MSR) to enable or disable a performance monitoring application or process to perform code-patching functions. If the code patching function is enabled, the application or process may patch code at run time by associating the metadata with the selected instructions. The metadata includes pointers pointing to the patch code block code. The program code may be patched autonomically without modifying original code.