Aspects include methods and apparatuses for effecting change over time in one or more measured regions of a body using a plurality of data sets obtained by analysis of applied signals to said region and effecting a change in treatment protocol. The method may include transmitting and receiving one or more of electromagnetic wave signals, applied acoustic wave signals and electrical signals transmitted through or reflected off of a portion of the measured body region. Some aspects may include determining a change in tissue structure, or a change in tissue content.