A compound of formula:
wherein X is S or O and A, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n, and m
are disclosed herein, or a pharmaceutically acceptable salt thereof (a
"Pyridazinylpiperazine Compound"), compositions comprising a
Pyridazinylpiperazine Compound, and methods for treating or preventing
pain, UI, an ulcer, IBD and IBS in an animal comprising administering to
an animal in need thereof an effective amount of a Pyridazinylpiperazine
Compound are disclosed herein.