A system and method for detecting if an object has been tampered with comprising a characterizer, a comparator, and indicator, and optionally, a signer. The characterizer generates a first digital characterization of an object at a first time and at least one subsequent digital characterization of the object at at least one subsequent time. The comparator compares the first digital characterization with the at least one subsequent digital characterization, and the indicator generates a pre-selected characterization signal if the first and subsequent digital characterizations don't match. Optionally, the first digital characterization can be accompanied by a first digital signature. The signer optionally verifies the digital signature at the at least one subsequent time.